Organic chemistry - 2CEMCH2

Goal(s)

Approach to basic reactivities in organic chemistry

Content(s)

• Reactivity in chemistry: general principles (electronic structure of molecules, nucleophiles, electrophiles,
  elementary acts, kinetic/thermodynamic control).
• Substitution and elimination reactions with
  halogens and alcohols derivatives - SN1, E1, SN2, E2 mechanisms and competition SN / E:
  stereochemical, kinetic aspect -activation of an alcohol function by tosylation –
  Williamson Synthesis example
• Addition reactions on carbonyl groups
  (aldehydes and ketones): hydrides, water, HCN, etc.
  Protection of carbonyl groups by acetalization
  Aldol reaction/ketolization
• Electrophilic addition reactions
  Addition reaction on alkenes and alkynes according to the Markovnikov selectivity.

*Labworks on experimental techniques:
TP1: Magnesium synthesis 4h
TP2: Synthesis of coumarin by Knoevenagel method 4h