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Grenoble INP Institut d'ingénierie et de management

Grenoble Institute of Engineering and Management
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Nanobiology

Field of study: Nanotechnologies

Level: Bachelor

Objectives: The aim of this course is to present how a natural biopolymer, can be used as a nanometric scaffold for the production of tunable structures. The DNA-based chemistry developped for more than 30 years brings a large panel of potentiel applications by grafting DNA strands on surfaces, nanoparticles, or proteins for instance. I propose an overview of the recent work illustrating the huge potential of DNA-based nanostructure for different applications.

I. DNA molecular structure and properties
- DNA and RNA chemical structures
- Biological functions of nucleic acids
- DNA (un)stability
- DNA synthesis (chemical and PCR-based)

II. Design of new functionalities for DNA
- Aptamers
- Data storage with DNA

III. DNA as a nanometric tunable object
- Seeman’s work
- DNA origamis, structures & design
- DNA based origamis for sensing
- DNA bricks
- DNA machines
- DNA multi-enzyme catalysts

IV. Some work completed in Grenoble
- DNA based nano-electronics

Lecture/contact hours: 3 hours 

Teaching language: English

Detailed examination modalities: written exam

Instructor: Dr. Yoann Roupioz
Department: Université Grenoble Alpes, Commissariat à l'énergie atomique et aux énergies alternatives (CEA) et Centre national de la recherche scientifique (CNRS).
e-mail: yoann.roupioz@cea.fr

 

Date of update April 7, 2021

French
Grenoble INP Institut d’ingénierie et de management, Université Grenoble Alpes
Grenoble INP, Graduate schools of Engineering and Management
Université Grenoble Alpes

(Institut polytechnique de Grenoble)
46 avenue Félix Viallet
F38031 Grenoble Cedex 1 - France
Tel. : +33 4 76 57 45 00 - Fax. : +33 4 76 57 45 01
 
 
             
Université Grenoble Alpes