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Nanobiology

Field of study: Nanotechnologies

Level: Bachelor

Objectives: The aim of this course is to present how a natural biopolymer, can be used as a nanometric scaffold for the production of tunable structures. The DNA-based chemistry developped for more than 30 years brings a large panel of potentiel applications by grafting DNA strands on surfaces, nanoparticles, or proteins for instance. I propose an overview of the recent work illustrating the huge potential of DNA-based nanostructure for different applications.

I. DNA molecular structure and properties
- DNA and RNA chemical structures
- Biological functions of nucleic acids
- DNA (un)stability
- DNA synthesis (chemical and PCR-based)

II. Design of new functionalities for DNA
- Aptamers
- Data storage with DNA

III. DNA as a nanometric tunable object
- Seeman’s work
- DNA origamis, structures & design
- DNA based origamis for sensing
- DNA bricks
- DNA machines
- DNA multi-enzyme catalysts

IV. Some work completed in Grenoble
- DNA based nano-electronics

Lecture/contact hours: 4.5 hours 

Teaching language: English

Detailed examination modalities: written exam

Instructor: Dr. Yoann Roupioz
Department: Université Grenoble Alpes, Commissariat à l'énergie atomique et aux énergies alternatives (CEA) et Centre national de la recherche scientifique (CNRS).
e-mail: yoann.roupioz@cea.fr


Date of update January 11, 2019

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